Sclerema neonatorum

Sclerema neonatorum

Specialty	Dermatology

Sclerema neonatorum is a rare and severe skin condition that is characterized by diffuse hardening of the subcutaneous tissue with minimal inflammation.^[1]^[2] It usually affects premature, ill newborns. Prognosis is poor.

Minimal inflammation helps distinguish sclerema neonaturum from subcutaneous fat necrosis of the newborn.

Sclerema neonatorum/pathology
Sclerema neonatorum/pathology

References

↑ William D. James, Timothy G. Berger; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. p. 490. ISBN 978-0-7216-2921-6.
↑ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. pp. 1515, 1524, 1525. ISBN 978-1-4160-2999-1.

External links

Classification	ICD-10: P83.0 ICD-9-CM: 778.1 MeSH: D012593 DiseasesDB: 31401
External resources	eMedicine: article/1112191

Disorders of subcutaneous fat

Panniculitis

Lobular	without vasculitis Cold Cytophagic histiocytic Factitial Gouty Pancreatic Traumatic needle-shaped clefts Subcutaneous fat necrosis of the newborn Sclerema neonatorum Post-steroid panniculitis Lipodermatosclerosis Weber–Christian disease Lupus erythematosus panniculitis Sclerosing lipogranuloma with vasculitis: Nodular vasculitis/Erythema induratum
Septal	without vasculitis: Alpha-1 antitrypsin deficiency panniculitis Erythema nodosum Acute Chronic with vasculitis: Superficial thrombophlebitis

Lipodystrophy

Acquired	generalized: Acquired generalized lipodystrophy partial: Acquired partial lipodystrophy Centrifugal abdominal lipodystrophy HIV-associated lipodystrophy Lipoatrophia annularis localized: Localized lipodystrophy
Congenital	Congenital generalized lipodystrophy Familial partial lipodystrophy Marfanoid–progeroid–lipodystrophy syndrome Poland syndrome

Conditions originating in the perinatal period / fetal disease

Maternal factors
complicating pregnancy,
labour or delivery

placenta	Placenta praevia Placental insufficiency Twin-to-twin transfusion syndrome
chorion/amnion	Chorioamnionitis
umbilical cord	Umbilical cord prolapse Nuchal cord Single umbilical artery
presentation	Breech birth Asynclitism Shoulder presentation

Growth

Birth trauma

Affected systems

Respiratory	Intrauterine hypoxia Infant respiratory distress syndrome Transient tachypnea of the newborn Meconium aspiration syndrome Pleural disease Pneumothorax Pneumomediastinum Wilson–Mikity syndrome Bronchopulmonary dysplasia
Cardiovascular	Pneumopericardium Persistent fetal circulation
Bleeding and hematologic disease	Vitamin K deficiency bleeding HDN ABO Anti-Kell Rh c Rh D Rh E Hydrops fetalis Hyperbilirubinemia Kernicterus Neonatal jaundice Velamentous cord insertion Intraventricular hemorrhage Germinal matrix hemorrhage Anemia of prematurity
Gastrointestinal	Ileus Necrotizing enterocolitis Meconium peritonitis
Integument and thermoregulation	Erythema toxicum Sclerema neonatorum
Nervous system	Perinatal asphyxia Periventricular leukomalacia
Musculoskeletal	Gray baby syndrome muscle tone Congenital hypertonia Congenital hypotonia

Infections

Other

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Sclerema neonatorum

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