Talk:Silver–Russell syndrome
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When I say Russell-Silver syndrome can cause HGH deficiency, I'm speaking from firsthand experience. I personally have RSS and was on growth hormone replacement therapy for 10 years. Please leave the bit about growth hormone deficiency as-is. Ataru 01:56, 14 September 2005 (UTC)
My objection was to the statement 'Continued poor growth with no "catch up" into the normal centile lines on growth chart, due to growth hormone deficiency' However many RSS patients with no catch up growth do not actually have HGH deficiency. In the UK growth hormone drugs have only recently been licensed for use in RSS because prior to that it had to be shown that a patient has growth hormone deficiency before these drugs could be used. Now the drugs are allowed because they do aid growth, even though there is not necessarily a deficiency. You canot extrapolate one case (your own) to all RSS cases because they are so varied. In RSS HGH will generally accelerate growth but may or may not increase final height: not enough studies have been done to know either way. As this is an encyclopedia it should contain facts and not speculations and not enough facts are yet know about HGH and RSS. I suggest something like: Growth hormone therapy may be used to aid growth, even in cases where the patient does not have a growth hormone deficiency. It is not yet clear whether Growth hormone therapy will increase final height, and if SRS and growth hormone deficiency are linked. What do you think? --Danio 09:54, 14 September 2005 (UTC)
- Yeah, that I could live with. Sorry to get a little defensive. Ataru 23:17, 14 September 2005 (UTC)
Changes to the first paragraph.
I've just made some changes. The paragraph said that Silver-Russell was one of 200 forms of primordial dwarfism. My undestanding of primordial dwarfism is that for a condition to be considered by that definition, the baby must be born significantly smaller ie. dwarfed. (excluding low birth size because of premature birth).
This does not include a great number of babies who are born with types of genetic dwarfism that will manifest as the baby starts to grow/mature, (but may be diagnosed at birth in many cases by an observant doctor). Such babies are not necessarily of low birth weight and they often have heads of a perfectly normal size.
In my observation children with true primordial dwarfism are tiny at birth, have small heads and birthweights that are in proportion to their short length and tiny limbs. Primordial dwarfism, as I understand it, is an exceptionally rare condition. I don't think it possible that 200 forms of primordial dwarfism could have been observed. It would be extremely hard to locate 200 people who had the condition in order to diagnose them!
I have read it stated on other websites that there are about 200 causes of dwarfism. The vast majority of these don't qualify as "primordial" and some of the other are not even "congenital".
--Amandajm 11:41, 5 February 2007 (UTC)
Article categorization
This article was initially categorized based on scheme outlined at WP:DERM:CAT. ---kilbad (talk) 16:36, 7 January 2010 (UTC)