Talk:GDF11

GDF-11 and heart health

Note to self. May want to mention this in the article. EIN (talk) 17:27, 9 May 2013 (UTC)

2nd article - here   — C M B J   22:13, 9 May 2013 (UTC)

The Cell result is not sufficient significant to mention in such a short stub article. This reeks of imbalance. 65.217.255.2 (talk) 18:41, 16 May 2013 (UTC)

I removed the reference to the Cell paper from Wagner and Lee, because in a stub article on an important human growth factor, one that highlights a recent result, which was almost reject from Cell because of lack of significance, placing it so far forward is indicative imbalanced presenation. There are hundreds of papers on BMP-11/GDF-11, including its role in fetal development. To pick one, rather curiously promoted, paper, which has not yet been reproduced, nor does it explain the mechanism involved clearly, is a violation of standards. Wikipedia is not for generating PR, but for notable and verifiable, results. As of yet whether this result is notable, or verifiable, has not yet been established to the degree that it warrants being one of three paragraphs on one of the beta superfamily. 65.217.255.2 (talk) 18:48, 16 May 2013 (UTC)

NYT article

"Young Blood May Hold Key to Reversing Aging" [[1]] This line of research warrants a sentence or two. It's possibly much more than just heart muscle.32cllou (talk) 21:29, 4 May 2014 (UTC)32cllou (talk) 21:31, 4 May 2014 (UTC)

• It apparently has rejuvenative effects on brain cells. -LesPaul75_talk 16:58, 27 May 2014 (UTC)

"Similar to myostatin"

For such a short article, there are maybe a few too many mentions of "similarity to myostatin":

• It is a myostatin-homologous protein
• pathway similar to that of myostatin
• similarities between GDF11 and myostatin
• GDF11 is closely related to myostatin
• Both myostatin and GDF11 are involved
• the similarities between myostatin and GDF11

It might read better if just one or two were removed. -LesPaul75_talk 17:09, 27 May 2014 (UTC)

Human Studies

The first line of the topic "Human Studies" states that "GDF11 levels fall to zero in humans at a mean age of 73.71." A relatively current study indicates that GDF-11 in humans does not decline with age, but GDF-8 does. The link to the study is https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10793994/ The title of the study is "GDF11 and aging biology - controversies resolved and pending" dated 2023 Oct 20. Take a look at the Graphical Abstract before the INTRODUCTION in this study. Then, search for "Total circulating GDF11 does not decline with age" in the study. Also, note that the majority of the authors are at Harvard University. Another JayOrman (talk) 20:59, 13 March 2024 (UTC)