Talk:AL amyloidosis

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Boston University Hospital BMT

Boston University Hospital has been successfully doing non-donor bone marrow transplants (BMT) since 1994 with very high cure rates. I don't have a source for this, but I know one of the first patients and read his manuscript. He was diagnosed in 1994 and he's alive and cured in 2009. Obviously this wouldn't count as a reliable source, so I'd urge someone with resources to look up "Patient H" - as I know he's been written up in some medical studies. Rklawton (talk) 15:06, 23 May 2009 (UTC)[reply]

Never mind, the sources provided included some of this information already, so I added it with citations under treatment. Rklawton (talk) 15:32, 23 May 2009 (UTC)[reply]
I double checked. As far as I know, BU's BMT long-term success has been limited to a single individual who also radically altered his diet. Rklawton (talk) 00:21, 3 May 2010 (UTC)[reply]


Article Assessment for WikiProject Medicine

Hello. I am a member of WikiProject Medicine, a Wikipedia wide project that maintains and improves articles that fall under the scope of medicine. Since your article has fallen under our scope, I have placed the correct template(s) on this talk page for verification. Upon reviewed of the article, I'd like to make a few points, as shown below:

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Leave a message on my talk page if you have any questions. I'm glad this article could fall within our scope, and I hope to see it grow large! Many thanks! Renaissancee (talk) 02:09, 17 June 2009 (UTC)[reply]

Cured of Amy

I double checked, and this website is self-published, so it probably doesn't meet our WP:EL guidelines. On the other hand, the author, "Patient H" has also been written up in some medical journals, so it's not the ordinary self-published crap we so often see. Thoughts about keeping the link? Maybe someone knows which journals and we could just link or cite those articles? Rklawton (talk) 00:21, 3 May 2010 (UTC)[reply]

Review source

Editors here might want to make use of the review

  • Wechalekar AD, Hawkins PN, Gillmore JD (2008). "Perspectives in treatment of AL amyloidosis". British Journal of Haematology. 140: 365–77.{{cite journal}}: CS1 maint: multiple names: authors list (link)

It was characterised as comprehensive at:

  • Hoffman J, Jhanwar S, Comenzo RL (March 2009). "AL amyloidosis and progression to multiple myeloma with gain(1q)". British Journal of Haematology. 144 (6): 963–4. doi:10.1111/j.1365-2141.2008.07536.x.{{cite journal}}: CS1 maint: multiple names: authors list (link)

LeadSongDog come howl! 16:59, 23 November 2011 (UTC)[reply]

Diagnosis - via biopsy of any tissue vs specifically from renal biopsy

The University of North Carolina website (citation #4) is from the department of nephrology. The page is focusing on renal manifestations. The actual quote pulled straight from the website is below 

"However, an actual diagnosis  requires a sample of an effected organ.  Although this can be any  organ, such as skin or bone marrow, this disease can only be diagnosed by looking at a piece of your kidney."

I think this wasn't worded very precisely. I think what is meant is that renal manifestations of AL amyloidosis can only be diagnosed via kidney biopsy, but AL amyloid can be diagnosed by demonstrating amyloid deposits composed of light chains in any organ such as skin or bone marrow. Not all patients with AL amyloidosis have renal involvement, so how would a renal biopsy be used to establish a diagnosis of AL amyloidosis in a patient without renal involvement?

See the section on diagnosis - see - http://cjasn.asnjournals.org/content/1/6/1331.full



Wawot1 (talk) 22:45, 30 November 2011 (UTC)[reply]

Ok. Fair enough. But you failed to cite your source. Please do so if you want to make changes.
Additionally, I'm a little perplexed by your edit summary here, b/c 1) light chains actually contain beta-pleated sheets (as do many other proteins), so there obviously are beta-pleated sheets floating around blood and urine, and 2) again, if you look at the source, you'll note that most of them talk about fragments, the rationale being that sometimes the amyloid protein is not a complete light chain, but instead a fragment of a light chain..... NickCT (talk) 03:58, 1 December 2011 (UTC)[reply]

Review

Br J Haem doi:10.1111/bjh.12191 JFW | T@lk 19:46, 7 January 2013 (UTC)[reply]

And now a British guideline: doi:10.1111/bjh.13155 JFW | T@lk 22:22, 13 October 2014 (UTC)[reply]
And another review doi:10.1111/bjh.13805 JFW | T@lk 09:30, 27 October 2015 (UTC)[reply]

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Merger proposal

I propose that Primary systemic amyloidosis be merged into AL Amyloidosis. I think that the content in Primary Systemic Amyloidosis article only poorly replicates part of the AL Amyloidosis page and should be merged/redirected to AL Amyloidosis the way that primary amyloidosis is. Red Fiona (talk) 18:24, 27 October 2017 (UTC)[reply]

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