Monokine
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A monokine is a type of cytokine[1] produced primarily by monocytes and macrophages.
Some monokines are:
- interleukin 1[2]
- tumor necrosis factor-alpha[2]
- alpha and beta interferon[3]
- colony stimulating factors [3]
Functions
Monokines released from macrophages can attract neutrophils, via the process chemotaxis.
The secretion of monokine, prompted by interferon gamma, has activity for the receptors found within immune cells, such as T-cells, hindering their ability to function as regulators of the body. Thus, promoting tumor progression in the cancer-state.[4] In fact, its activity is important in other diseases, such as pulmonary tuberculosis, where researchers have identified monokine as a biomarker.[5]
See also
References
- ^ Monokines at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- ^ a b Leung DY, Geha RS, Newburger JW (1986). "Two monokines, interleukin 1 and tumor necrosis factor, render cultured vascular endothelial cells susceptible to lysis by antibodies circulating during Kawasaki syndrome". The Journal of Experimental Medicine. 164 (6): 1958–72. doi:10.1084/jem.164.6.1958. PMC 2188474. PMID 3491174.
- ^ a b Julius M. Cruse; Robert Edwin Lewis (20 April 2009). Illustrated dictionary of immunology. CRC Press. pp. 208–. ISBN 978-0-8493-7987-1. Retrieved 24 April 2011.
- ^ Bolomsky, Arnold; Schreder, Martin; Hübl, Wolfgang; Zojer, Niklas; Hilbe, Wolfgang; Ludwig, Heinz (November 2016). "Monokine induced by interferon gamma (MIG/CXCL9) is an independent prognostic factor in newly diagnosed myeloma". Leukemia & Lymphoma. 57 (11): 2516–2525. doi:10.3109/10428194.2016.1151511. ISSN 1042-8194. PMID 26999330.
- ^ Li, Yang; He, Dengqi; Che, Yinfu; Zhao, Xinchen (2020-11-20). "Monokine induced by gamma interferon for detecting pulmonary tuberculosis: A diagnostic meta-analysis". Medicine. 99 (47): e23302. doi:10.1097/MD.0000000000023302. ISSN 0025-7974. PMC 7676613. PMID 33217864.
External links
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