Cotrifazid

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Cotrifazid
Combination of
RifampicinAnti-tuberculosis medication
IsoniazidAnti-tuberculosis medication
SulfamethoxazoleSulfonamide
TrimethoprimAntibiotic
Clinical data
Pregnancy
category
  • AU: C
Routes of
use		oral
Legal
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: ℞-only


Cotrifazid is a treatment and prophylaxis for malaria consisting of a multiple complex combination of rifampicin, isoniazid, sulfamethoxazole, and trimethoprim.[1]

Clinical study

This medication has been deemed an adequate treatment, however further evaluation indicated that mefloquine and the combination of quinine with sulfadoxine-pyrimethamine was more effective against certain cases of malaria[2][3]

References

  1. ↑ Freerksen E; et al. (September–October 1995). "Malaria therapy and prophylaxis with cotrifazid, a multiple complex combination consisting of rifampicin + isoniazid + sulfamethoxazole + trimethoprim". Chemotherapy. 41 (5): 396–8. doi:10.1159/000239372. PMID 8521742.
  2. ↑ Genton, Blaise; Mueller, Ivo; Betuela, Inoni; Casey, Gerard; Ginny, Meza; Alpers, Michael P; Reeder, John C (22 December 2006). "Rifampicin/Cotrimoxazole/Isoniazid Versus Mefloquine or Quinine + Sulfadoxine- Pyrimethamine for Malaria: A Randomized Trial". PLoS Clinical Trials. 1 (8): e38. doi:10.1371/journal.pctr.0010038. ISSN 1555-5887. Archived from the original on 20 January 2024. Retrieved 17 January 2024.
  3. ↑ Fontinha, Diana; Moules, Isabel; Prudêncio, Miguel (28 July 2020). "Repurposing Drugs to Fight Hepatic Malaria Parasites". Molecules. 25 (15): 3409. doi:10.3390/molecules25153409. ISSN 1420-3049. Archived from the original on 20 January 2024. Retrieved 17 January 2024.


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