Rheumatoid neutrophilic dermatitis

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Rheumatoid neutrophilic dermatitis
SpecialtyDermatology

Rheumatoid neutrophilic dermatitis, also known as rheumatoid neutrophilic dermatosis,[1] is a cutaneous condition associated with rheumatoid arthritis.[2]

Signs and symptoms

Rheumatoid neutrophilic dermatitis occurs more frequently in patients with severe, persistent seropositive arthritis; it presents clinically as erythematous papules, nodules, plaques, or lesions resembling urticaria without any accompanying symptoms.[3][4][5] Less common conditions include annular lesions, blisters, ulcers, and vesicles.[6][7] Skin lesions are typically symmetrical, but they can occasionally be distributed asymmetrically.[8][9] Dorsal surfaces of hands and arms are preferred sites, with an emphasis on the extensor surfaces of extremities and joints.[10][11][12]

Diagnosis

Histopathological findings include normal epidermis, that may show hyperkeratosis, parakeratosis,[13] focal ulceration with scaly crust,[14] or spongiosis with intraepidermal blistering,[15]

Treatment

Treatments include topical steroids,[16] cyclophosphamide,[17] dapsone,[13] and hydroxychloroquine.[14]

Outlook

Lesion resolution can happen on its own or as the rheumatoid arthritis progresses, but lesions usually recur when the condition gets worse. Although most lesions heal without leaving scars, hyperpigmentation may linger for a while.[18]

See also

References

  1. ^ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. Page 180. ISBN 0-7216-2921-0.
  2. ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
  3. ^ Xue, Yun; Cohen, Jeffrey M.; Wright, Natalie A.; Merola, Joseph F. (December 9, 2015). "Skin Signs of Rheumatoid Arthritis and its Therapy-Induced Cutaneous Side Effects". American Journal of Clinical Dermatology. 17 (2). Springer Science and Business Media LLC: 147–162. doi:10.1007/s40257-015-0167-z. ISSN 1175-0561. PMID 26649439. S2CID 42706531.
  4. ^ Ziemer, Mirjana; Müller, Anne-Katrin; Hein, Gert; Oelzner, Peter; Elsner, Peter (November 25, 2016). "Incidence and classification of cutaneous manifestations in rheumatoid arthritis". JDDG: Journal der Deutschen Dermatologischen Gesellschaft. 14 (12). Wiley: 1237–1246. doi:10.1111/ddg.12680. ISSN 1610-0379. PMID 27886444. S2CID 3424646.
  5. ^ Hata, Tissa; Kavanaugh, Arthur (2006). "Rheumatoid arthritis in dermatology". Clinics in Dermatology. 24 (5). Elsevier BV: 430–437. doi:10.1016/j.clindermatol.2006.07.008. ISSN 0738-081X. PMID 16966022.
  6. ^ Fujio, Yumi; Funakoshi, Takeru; Nakayama, Kaori; Amagai, Masayuki; Ohyama, Manabu (October 25, 2012). "Rheumatoid neutrophilic dermatosis with tense blister formation: A case report and review of the literature". Australasian Journal of Dermatology. 55 (1). Wiley: e12–e14. doi:10.1111/j.1440-0960.2012.00963.x. ISSN 0004-8380. PMID 23094684. S2CID 39668337.
  7. ^ Filosa, Alessandra; Filosa, Giorgio (2018). "Neutrophilic dermatoses: a broad spectrum of disease". Italian Journal of Dermatology and Venereology. 153 (2). Edizioni Minerva Medica: 265–272. doi:10.23736/s0392-0488.18.05841-8. ISSN 2784-8671. PMID 29368857.
  8. ^ Brown, Timothy S.; Fearneyhough, Paul K.; Burruss, Jyoti B.; Callen, Jeffrey P. (2001). "Rheumatoid neutrophilic dermatitis in a woman with seronegative rheumatoid arthritis". Journal of the American Academy of Dermatology. 45 (4). Elsevier BV: 596–600. doi:10.1067/mjd.2001.119031. ISSN 0190-9622. PMID 11568753.
  9. ^ Chua-Aguilera, Carolyn Jean; Möller, Burkhard; Yawalkar, Nikhil (July 27, 2017). "Skin Manifestations of Rheumatoid Arthritis, Juvenile Idiopathic Arthritis, and Spondyloarthritides". Clinical Reviews in Allergy & Immunology. 53 (3). Springer Science and Business Media LLC: 371–393. doi:10.1007/s12016-017-8632-5. ISSN 1080-0549. PMID 28752373. S2CID 43240243.
  10. ^ DeFaria, Doreen; Kroumpouzos, George (May 1, 2004). "Rheumatoid Neutrophilic Dermatitis as Presenting Sign of Seronegative Arthritis". Acta Dermato-Venereologica. 84 (3). Medical Journals Sweden AB: 236–237. doi:10.1080/00015550310007724. ISSN 0001-5555. PMID 15202847.
  11. ^ Ashchyan, Hovik J.; Nelson, Caroline A.; Stephen, Sasha; James, William D.; Micheletti, Robert G.; Rosenbach, Misha (2018). "Neutrophilic dermatoses". Journal of the American Academy of Dermatology. 79 (6). Elsevier BV: 1009–1022. doi:10.1016/j.jaad.2017.11.063. ISSN 0190-9622. PMID 29653213. S2CID 4896415.
  12. ^ Caucanas, Marie; Heylen, Alain; Rolland, Florence; Müller, Gebhard; Olemans, Catherine; Sass, Ursulla; Vanhooteghem, Olivier (September 23, 2013). "Associated pyoderma gangrenosum, erythema elevatum diutinum, and Sweet's syndrome: the concept of neutrophilic disease". International Journal of Dermatology. 52 (10). Wiley: 1185–1188. doi:10.1111/j.1365-4632.2011.05415.x. ISSN 0011-9059. PMID 24073904. S2CID 8539323.
  13. ^ a b Bouffard, D. (October 1, 1995). "Long-standing verrucous lesion. Chromomycosis". Archives of Dermatology. 131 (10). American Medical Association (AMA): 1195b–1196. doi:10.1001/archderm.131.10.1195b. ISSN 0003-987X. PMID 7574838.
  14. ^ a b Sánchez, Jorge L.; Cruz, Alma (1990). "Rheumatoid neutrophilic dermatitis". Journal of the American Academy of Dermatology. 22 (5). Elsevier BV: 922–925. doi:10.1016/0190-9622(90)70127-4. ISSN 0190-9622. PMID 2335586.
  15. ^ Lowe, Lori; Kornfeld, Bruce; Clayman, Joseph; Golitz, Loren E. (1992). "Rheumatoid neutrophilic dermatitis". Journal of Cutaneous Pathology. 19 (1). Wiley: 48–53. doi:10.1111/j.1600-0560.1992.tb01558.x. ISSN 0303-6987. PMID 1556266. S2CID 31454442.
  16. ^ Hirota, T K; Keough, G C; David-Bajar, K; McCollough, M L (October 1997). "Rheumatoid neutrophilic dermatitis". Cutis. 60 (4): 203–205. PMID 9347237.
  17. ^ Mashek, Helen A. (1997-06-01). "Rheumatoid Neutrophilic Dermatitis". Archives of Dermatology. 133 (6): 757–760. doi:10.1001/archderm.1997.03890420097013. ISSN 0003-987X. PMID 9197831.
  18. ^ Lazarov, A; Mor, A; Cordoba, M; Mekori, Ya (2002). "Rheumatoid neutrophilic dermatitis: an initial dermatological manifestation of seronegative rheumatoid arthritis". Journal of the European Academy of Dermatology and Venereology. 16 (1): 74–76. doi:10.1046/j.1468-3083.2002.00401.x. ISSN 0926-9959. PMID 11952297. S2CID 30236685.

Further reading

External links

Retrieved from "https://mdwiki.org/wiki/Rheumatoid_neutrophilic_dermatitis"