Paraneoplastic acrokeratosis, also known as Bazex syndrome, is a skin sign associated with cancer.[2] It is characterized by psoriasiform changes of hands, feet, ears, and nose, with involvement of the nails and periungual tissues being characteristic and indistinguishable from psoriatic nails. The condition is associated with carcinomas of the upper aerodigestive tract.[3]: 665
a) Dark red, infiltrative, desquamative plaques on nose/cheeks b) dark red, infiltrative plaques with scales on auricle c) confluent erythema on knees d) infiltrative erythematous plaques with scales ; all fingernails were yellow-brown/thickened e) both plantar pedis were discolored/hyperkeratotic
a-b) After treatment with gefinitib
Dystrophic nails in a patient with laryngeal squamous cell carcinoma
↑Gougerot, H. and Grupper, C., (1922). Dermatose érythémato-squameuse avec hyperkératose palmoplantaire, porectasies digitales et cancer de la langue latent. Paris Med, 43, pp.234-237