Keratosis punctata of the palmar creases

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Keratosis punctata of the palmar creases
Other names: Hyperkeratosis penetrans, Hyperkeratosis punctata, Keratodermia punctata, Keratosis punctata, Keratotic pits of the palmar creases, Lenticular atrophia of the palmar creases, and Punctate keratosis of the palmar creases
Keratosis punctata 1.png
Keratosis punctata of the palmar creases
SpecialtyDermatology
SymptomsSmall depressions in the skin creases of palms and soles, filled with comedo-like keratinous plugs[1]
CausesInherited (autosomal dominant)[2]
Risk factorsAfrican descent[2]
Diagnostic methodAppearance[1]
Differential diagnosisFocal acral hyperkeratosis[2]
TreatmentKeratolytics, topical retinoids, surgery[2]

Keratosis punctata of the palmar creases (PKPC) are small (less than 5mm) round depressions in the skin creases of palms, fingers and to a lesser extent the soles, which are filled with comedo-like keratinous plugs.[1] It may appear simultaneously with atopic dermatitis, be associated with manual labour, and worsen by friction.[2] Some are painful.[2]

PKPC runs in families and is inherited as autosomal dominant, most frequently occurring in people of African descent.[2] Diagnosis is by its appearance.[2][3] It may appear similar to focal acral hyperkeratosis.[2]

Applying keratolytics or retinoids may help.[2] Surgically removing them is another option.[2] They likely recur.[2]

The condition was first described by Rasmussen in 1980.[2]

See also

References

  1. 1.0 1.1 1.2 James, William D.; Elston, Dirk; Treat, James R.; Rosenbach, Misha A.; Neuhaus, Isaac (2020). "11. Pityriasis rosea, pityriasis rubra pilares, and other papulosquamous and hyperkeratotic diseases". Andrews' Diseases of the Skin: Clinical Dermatology (13th ed.). Edinburgh: Elsevier. pp. 209–210. ISBN 978-0-323-54753-6. Archived from the original on 2023-02-27. Retrieved 2023-02-27.
  2. 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 Hines, Aliya Courtney; Moin, Moin (2020). "2. Common skin conditions in black skin". In Moiin, Ali (ed.). Atlas of Black Skin. Springer. pp. 36–44. ISBN 978-3-030-31484-2. Archived from the original on 2023-02-27. Retrieved 2023-02-27.
  3. Thomas, Bjorn R.; O'Toole, Edel A. (25 March 2020). "Diagnosis and Management of Inherited Palmoplantar Keratodermas". Acta Dermato-Venereologica. 100 (7): adv00094. doi:10.2340/00015555-3430. ISSN 1651-2057. PMID 32147745. Archived from the original on 11 April 2022. Retrieved 10 April 2022.