File:Septins and TTFields.jpg

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Image title	Model for TTFields action leading to mitotic disruption.During mitosis, the Septin 2, 6, 7 complex is recruited to the Anaphase spindle midline and the cytokinetic cleavage furrow by Anillin where it self-assembles into a fibrous lattice due to lateral interactions between parallel Septin filaments. By inducing rotational movement within the parallel fibers at a slightly less more than a right angle to their lateral axis, TTFields are able to inhibit the propagation of lattice formation by disrupting the ability of individual fibers to bind each other. In the absence of proper Septin function, contractile elements of the cytokinetic furrow are not restrained within the equatorial midline of the cell resulting in ectopic furrow malfunction that leads to violent membrane contractions at the onset of anaphase followed by aberrant mitotic exit.
Publisher	Public Library of Science
Short title	Fig 5
Copyright holder	Creative Commons Attribution License
Source	info:doi/10.1371/journal.pone.0125269
Date(s)	26 May 2015
Identifier	info:doi/info:doi/10.1371/journal.pone.0125269.g005