File:Pharmaceuticals-15-00048-g001.jpg
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Summary
| Description |
English: Alternate mechanisms of JAK inhibition. Deucravacitinib inhibits TYK2 activation by interacting with the pseudokinase (JH2) domain (allosteric inhibition), while first-generation jakinibs inhibit enzymatic activity by binding to the ATP-binding (JH1) domain (competitive inhibition). |
| Date | |
| Source | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779366/ |
| Author | Madison Alexander, Yiming Luo, Giorgio Raimondi, John J. O’Shea, and Massimo Gadina |
Licensing
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 21:08, 20 December 2023 | | 743 × 552 (112 KB) | commons>Ozzie10aaaa | Uploaded a work by Madison Alexander, Yiming Luo, Giorgio Raimondi, John J. O’Shea, and Massimo Gadina from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779366/ with UploadWizard |
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