File:DDDT-137783-F01.jpg

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DDDT-137783-F01.jpg ‎(554 × 487 pixels, file size: 27 KB, MIME type: image/jpeg)

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Summary

Description
English: Figure 1 Mode of action of CDK4/6 inhibitors.

Notes: Palbociclib, ribociclib and abemaciclib inhibit the complex CDK4/cyclin D1, responsible for the phosphorylation and inhibition of the Rb tumor-suppressor gene’s product. When Rb is phosphorylated, the cell proceeds from G1 to Phase S of the cell cycle, replicating DNA and preparing for mitosis.

Abbreviation: Rb, retinoblastoma.
Date
Source https://www.dovepress.com/abemaciclib-a-cdk46-inhibitor-for-the-treatment-of-hrher2-advanced-bre-peer-reviewed-fulltext-article-DDDT
Author Corona SP , Generali D
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Image extraction processThis file has an extracted image: DDDT-137783-F01 (cropped).jpg.
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current18:41, 19 March 2024Thumbnail for version as of 18:41, 19 March 2024554 × 487 (27 KB)Ozzie10aaaa
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