Clear cell acanthoma
| Clear cell acanthoma | |
|---|---|
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| Clear cell acanthoma (Degos) | |
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Clear cell acanthoma (also known as "Acanthome cellules claires of Degos and Civatte," "Degos acanthoma," and "Pale cell acanthoma") is a benign clinical and histological lesion initially described as neoplastic, which some authors now regard as a reactive dermatosis.
Signs and symptoms
It usually presents as a moist solitary firm, brown-red, well-circumscribed, 5 mm to 2 cm nodule or plaque on the lower extremities of middle-aged to elderly individuals The lesion has a crusted, scaly peripheral collarette and vascular puncta on the surface. It is characterized by slow growth, and may persist for years.
Histology
Clear cell acanthoma is characterized by a sharply demarcated psoriasiform epidermal hyperplasia composed of a proliferation of slightly enlarged keratinocytes, and basal cells with pale-staining glycogen-rich cytoplasm, mild spongiosis and scattered neutrophils, which may form small intraepidermal microabscesses. Oedematous dermal papillae are typically seen with increased vascularity and a mixed inflammatory infiltrate including lymphocytes, plasma cells and neutrophils.
Diagnosis
Differential diagnosis
The clinical differential diagnosis includes: dermatofibroma, inflamed seborrheic keratosis, pyogenic granuloma, basal cell carcinoma, squamous cell carcinoma, verruca vulgaris, psoriatic plaque, and melanoma.
Treatment
Simple surgical excision is curative. [1]: 636 [2]: 777 Cryosurgery is the use of extreme cold in surgery to destroy abnormal or diseased tissue[3]Cryotherapy or cold therapy, is the local,as well as general use of low temperatures in medical therapy[4]
See also
- Epidermis
- List of cutaneous conditions
- List of cutaneous neoplasms associated with systemic syndromes
References
- ↑ Odom, Richard B.; Davidsohn, Israel; James, William D.; Henry, John Bernard; Berger, Timothy G.; Clinical diagnosis by laboratory methods; Dirk M. Elston (2006). Andrews' diseases of the skin: clinical dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
- ↑ Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0-07-138076-0.
- ↑ "Cryotherapy - DermNet New Zealand". dermnetnz.org. Archived from the original on 2006-10-24. Retrieved 2022-04-12.
- ↑ Prohaska, Joseph; Jan, Abdul H. (2022). "Cryotherapy". StatPearls. StatPearls Publishing. Retrieved 12 April 2022.